› 3a03

X-ray diffraction
1.54Å resolution

Crystal structure of Hox11L1 homeodomain

Released:
DOI: 10.2210/pdb3a03/pdb
PDB entry 3a03 coloured by chain, front view.
PDB entry 3a03 coloured by chain, side view.
PDB entry 3a03 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.
Miyazono K, Zhi Y, Takamura Y, Nagata K, Saigo K, Kojima T, Tanokura M
EMBO J 29 1613-23 (2010)
PMID: 20389279

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-129103 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell leukemia homeobox protein 2 Chain: A
Molecule details ›
Chain: A
Length: 56 amino acids
Theoretical weight: 6.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43763 (Residues: 162-216; Coverage: 19%)
Gene names: HOX11L1, NCX, TLX2
Sequence domains: Homeodomain
Structure domains: Homeodomain-like

Ligands and Environments

2 bound ligands:
Ligand NA 1 x NA
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: C2
Unit cell:
a: 73.06Å b: 33.17Å c: 34.43Å
α: 90° β: 102.12° γ: 90°
R-values:
R R work R free
0.201 0.2 0.223
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster.
Takai et al. (2020)
21 other articles

6 mentions without citation

Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.
Miyazono et al. (2010)
5 more