› 3a07

X-ray diffraction
1.19Å resolution

Crystal Structure of Actinohivin; Potent anti-HIV Protein

Released:
DOI: 10.2210/pdb3a07/pdb
PDB entry 3a07 coloured by chain, front view.
PDB entry 3a07 coloured by chain, side view.
PDB entry 3a07 coloured by chain, top view.
Source organism: actinomycete K97-0003
Primary publication:
Mechanism by which the lectin actinohivin blocks HIV infection of target cells.
Tanaka H, Chiba H, Inokoshi J, Kuno A, Sugai T, Takahashi A, Ito Y, Tsunoda M, Suzuki K, Takénaka A, Sekiguchi T, Umeyama H, Hirabayashi J, Omura S
Proc Natl Acad Sci U S A 106 15633-8 (2009)
PMID: 19717426

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192153 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actinohivin Chains: A, B
Molecule details ›
Chains: A, B
Length: 118 amino acids
Theoretical weight: 12.97 KDa
Source organism: actinomycete K97-0003
UniProt:
  • Canonical: Q9KWN0 (Residues: 43-160; Coverage: 88%)
Gene name: ath
Sequence domains: Ricin-type beta-trefoil lectin domain
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:
Ligand NA 6 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: C2221
Unit cell:
a: 47.346Å b: 51.633Å c: 175.296Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.15 0.149 0.163

Quick links

Citations

13 review citations

Targeting cell entry of enveloped viruses as an antiviral strategy.
Teissier et al. (2010)
12 more

6 mentions without citation

Mannose-Specific Lectins from Marine Algae: Diverse Structural Scaffolds Associated to Common Virucidal and Anti-Cancer Properties.
Barre et al. (2019)
5 more