› 3a0c

X-ray diffraction
2Å resolution

Crystal Structure of an anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua

Released:
DOI: 10.2210/pdb3a0c/pdb
PDB entry 3a0c coloured by chain, front view.
PDB entry 3a0c coloured by chain, side view.
PDB entry 3a0c coloured by chain, top view.
Source organism: Polygonatum cyrtonema
Primary publication:
Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure.
Ding J, Bao J, Zhu D, Zhang Y, Wang DC
J Struct Biol 171 309-17 (2010)
PMID: 20546901

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185253 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bulb-type lectin domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 110 amino acids
Theoretical weight: 11.96 KDa
Source organism: Polygonatum cyrtonema
UniProt:
  • Canonical: Q8L568 (Residues: 29-138; Coverage: 83%)
Structure domains: Bulb-type lectin domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P21
Unit cell:
a: 39.308Å b: 48.317Å c: 112.221Å
α: 90° β: 90.12° γ: 90°
R-values:
R R work R free
0.233 0.233 0.271

Quick links

Citations

11 review citations

Antiviral lectins: Selective inhibitors of viral entry.
Mitchell et al. (2017)
10 more

2 mentions without citation

Camphor, Artemisinin and Sumac Phytochemicals as inhibitors against COVID-19: Computational approach.
Belhassan et al. (2021)
1 more