› 3a0d

X-ray diffraction
2.2Å resolution

Crystal Structure of Polygonatum cyrtonema lectin (PCL) complexed with monomannoside

Released:
DOI: 10.2210/pdb3a0d/pdb
PDB entry 3a0d coloured by chain, front view.
PDB entry 3a0d coloured by chain, side view.
PDB entry 3a0d coloured by chain, top view.
Source organism: Polygonatum cyrtonema
Primary publication:
Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure.
Ding J, Bao J, Zhu D, Zhang Y, Wang DC
J Struct Biol 171 309-17 (2010)
PMID: 20546901

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185253 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bulb-type lectin domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 110 amino acids
Theoretical weight: 11.96 KDa
Source organism: Polygonatum cyrtonema
UniProt:
  • Canonical: Q8L568 (Residues: 29-138; Coverage: 83%)
Structure domains: Bulb-type lectin domain

Ligands and Environments

2 bound ligands:
Ligand MMA 1 x MMA
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P3221
Unit cell:
a: 76.46Å b: 76.46Å c: 61.75Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.198 0.217

Quick links

Citations

9 review citations

Antiviral lectins: Selective inhibitors of viral entry.
Mitchell et al. (2017)
8 more

2 mentions without citation

Man-Specific Lectins from Plants, Fungi, Algae and Cyanobacteria, as Potential Blockers for SARS-CoV, MERS-CoV and SARS-CoV-2 (COVID-19) Coronaviruses: Biomedical Perspectives.
Barre et al. (2021)
1 more