› 3a0e

X-ray diffraction
2Å resolution

Crystal Structure of Polygonatum cyrtonema lectin (PCL) complexed with dimannoside

Released:
DOI: 10.2210/pdb3a0e/pdb
PDB entry 3a0e coloured by chain, front view.
PDB entry 3a0e coloured by chain, side view.
PDB entry 3a0e coloured by chain, top view.
Source organism: Polygonatum cyrtonema
Primary publication:
Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure.
Ding J, Bao J, Zhu D, Zhang Y, Wang DC
J Struct Biol 171 309-17 (2010)
PMID: 20546901

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185253 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Bulb-type lectin domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 110 amino acids
Theoretical weight: 11.96 KDa
Source organism: Polygonatum cyrtonema
UniProt:
  • Canonical: Q8L568 (Residues: 29-138; Coverage: 83%)
Structure domains: Bulb-type lectin domain

Ligands and Environments

Carbohydrate polymer : NEW Components: MAN
Carbohydrate polymer
1 bound ligand:
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 1W2B
Spacegroup: P3221
Unit cell:
a: 76.66Å b: 76.66Å c: 61.401Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.19 0.212

Quick links

Citations

10 review citations

Lectins with anti-HIV activity: a review.
Akkouh et al. (2015)
9 more

3 mentions without citation

Antiviral lectins: Selective inhibitors of viral entry.
Mitchell et al. (2017)
2 more