› 3a7b

X-ray diffraction
2.53Å resolution

Crystal structure of TLR2-Streptococcus Pneumoniae lipoteichoic acid complex

Released:
DOI: 10.2210/pdb3a7b/pdb
PDB entry 3a7b coloured by chain, front view.
PDB entry 3a7b coloured by chain, side view.
PDB entry 3a7b coloured by chain, top view.
Source organisms:
Primary publication:
Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.
Kang JY, Nan X, Jin MS, Youn SJ, Ryu YH, Mah S, Han SH, Lee H, Paik SG, Lee JO
Immunity 31 873-84 (2009)
PMID: 19931471

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175537 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
LRRNT domain-containing protein; Toll-like receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 580 amino acids
Theoretical weight: 65.54 KDa
Source organisms: Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9QUN7 (Residues: 1-506; Coverage: 63%)
  • Canonical: Q4G1L2 (Residues: 133-200; Coverage: 27%)
Gene names: Tlr2, VLRB
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 1 x NAG
Ligand LTC 1 x LTC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 68.578Å b: 83.19Å c: 214.658Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.234 0.27
Expression system: Trichoplusia ni

Quick links

Citations

142 review citations

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.
Kawai et al. (2010)
141 more

12 mentions without citation

The structural biology of Toll-like receptors.
Botos et al. (2011)
11 more