› 3a7q

X-ray diffraction
2.6Å resolution

Structural basis for specific recognition of reelin by its receptors

Released:
DOI: 10.2210/pdb3a7q/pdb
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PDB entry 3a7q coloured by chain, front view.
PDB entry 3a7q coloured by chain, side view.
PDB entry 3a7q coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for specific recognition of reelin by its receptors.
Yasui N, Nogi T, Takagi J
Structure 18 320-31 (2010)
PMID: 20223215

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-171912 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Reelin Chain: A
Molecule details ›
Chain: A
Length: 725 amino acids
Theoretical weight: 81.32 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q60841 (Residues: 1948-2661; Coverage: 21%)
Gene names: Reln, Rl
Sequence domains: Reelin subrepeat B
Structure domains: Galactose-binding domain-like
Low-density lipoprotein receptor-related protein 8 Chain: B
Molecule details ›
Chain: B
Length: 44 amino acids
Theoretical weight: 5.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14114 (Residues: 42-83; Coverage: 5%)
Gene names: APOER2, LRP8
Sequence domains: Low-density lipoprotein receptor domain class A

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 3 x NAG
Ligand CA 5 x CA
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P21
Unit cell:
a: 56.98Å b: 93.844Å c: 73.456Å
α: 90° β: 107.41° γ: 90°
R-values:
R R work R free
0.227 0.223 0.296
Expression systems:
  • Cricetulus griseus
  • Escherichia coli

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Citations

10 review citations

New Insights into Reelin-Mediated Signaling Pathways.
Lee et al. (2016)
9 more

8 mentions without citation

Low-density lipoprotein receptor-related protein-1: role in the regulation of vascular integrity.
Strickland et al. (2014)
7 more

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