› 3ajm

X-ray diffraction
2.3Å resolution

Crystal structure of programmed cell death 10 in complex with inositol 1,3,4,5-tetrakisphosphate

Released:
DOI: 10.2210/pdb3ajm/pdb
PDB entry 3ajm coloured by chain, front view.
PDB entry 3ajm coloured by chain, side view.
PDB entry 3ajm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human programmed cell death 10 complexed with inositol-(1,3,4,5)-tetrakisphosphate: a novel adaptor protein involved in human cerebral cavernous malformation.
Ding J, Wang X, Li DF, Hu Y, Zhang Y, Wang DC
Biochem Biophys Res Commun 399 587-92 (2010)
PMID: 20682288

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189740 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Programmed cell death protein 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 213 amino acids
Theoretical weight: 24.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BUL8 (Residues: 8-212; Coverage: 97%)
Gene names: CCM3, PDCD10, TFAR15
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 4IP 1 x 4IP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P41212
Unit cell:
a: 89.83Å b: 89.83Å c: 114.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.264
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Cerebral cavernous malformation proteins at a glance.
Draheim et al. (2014)
3 more

2 mentions without citation

Molecular recognition of leucine-aspartate repeat (LD) motifs by the focal adhesion targeting homology domain of cerebral cavernous malformation 3 (CCM3).
Li et al. (2011)
1 more