› 3alw

X-ray diffraction
3.55Å resolution

Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM (Form I, MV-H-SLAM(N102H/R108Y) fusion)

Released:
DOI: 10.2210/pdb3alw/pdb
PDB entry 3alw coloured by chain, front view.
PDB entry 3alw coloured by chain, side view.
PDB entry 3alw coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM.
Hashiguchi T, Ose T, Kubota M, Maita N, Kamishikiryo J, Maenaka K, Yanagi Y
Nat Struct Mol Biol 18 135-41 (2011)
PMID: 21217702

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer (preferred)
homo hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-140102 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin glycoprotein; Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 559 amino acids
Theoretical weight: 62.08 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P08362 (Residues: 184-607; Coverage: 69%)
  • Canonical: Q9GJT3 (Residues: 24-140; Coverage: 37%)
Gene names: CDw150, H
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P6322
Unit cell:
a: 209.912Å b: 209.912Å c: 180.538Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.25 0.25 0.283
Expression system: Homo sapiens

Quick links

Citations

35 review citations

Paramyxovirus fusion and entry: multiple paths to a common end.
Chang et al. (2012)
34 more

8 mentions without citation

Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses.
Rissanen et al. (2017)
7 more