› 3alx

X-ray diffraction
3.15Å resolution

Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM (MV-H(L482R)-SLAM(N102H/R108Y) fusion)

Released:
DOI: 10.2210/pdb3alx/pdb
PDB entry 3alx coloured by chain, front view.
PDB entry 3alx coloured by chain, side view.
PDB entry 3alx coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM.
Hashiguchi T, Ose T, Kubota M, Maita N, Kamishikiryo J, Maenaka K, Yanagi Y
Nat Struct Mol Biol 18 135-41 (2011)
PMID: 21217702

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-122866 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin glycoprotein; Ig-like domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 559 amino acids
Theoretical weight: 62.12 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: E2RZS2 (Residues: 184-607; Coverage: 69%)
  • Canonical: Q9GJT3 (Residues: 24-140; Coverage: 37%)
Gene names: CDw150, H
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: C2
Unit cell:
a: 187.713Å b: 170.074Å c: 110.681Å
α: 90° β: 117.28° γ: 90°
R-values:
R R work R free
0.231 0.231 0.292
Expression system: Homo sapiens

Quick links

Citations

33 review citations

Paramyxovirus fusion and entry: multiple paths to a common end.
Chang et al. (2012)
32 more

9 mentions without citation

Measles Virus Fusion Protein: Structure, Function and Inhibition.
Plattet et al. (2016)
8 more