› 3anp

X-ray diffraction
1.95Å resolution

Crystal structure of Thermus thermophilus FadR, a TetR familly transcriptional repressor, in complex with lauroyl-CoA.

Released:
DOI: 10.2210/pdb3anp/pdb
PDB entry 3anp coloured by chain, front view.
PDB entry 3anp coloured by chain, side view.
PDB entry 3anp coloured by chain, top view.
Source organism: Thermus thermophilus
Primary publication:
TetR-family transcriptional repressor Thermus thermophilus FadR controls fatty acid degradation.
Agari Y, Agari K, Sakamoto K, Kuramitsu S, Shinkai A
Microbiology (Reading) 157 1589-1601 (2011)
PMID: 21349973

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178247 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH tetR-type domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 204 amino acids
Theoretical weight: 23.71 KDa
Source organism: Thermus thermophilus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5SM42 (Residues: 2-205; Coverage: 100%)
Gene name: TTHA0101
Sequence domains:
Structure domains: Tetracycline Repressor, domain 2

Ligands and Environments

2 bound ligands:
Ligand DCC 3 x DCC
Ligand DAO 1 x DAO
1 modified residue:
Ligand MSE 16 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P212121
Unit cell:
a: 98.907Å b: 104.529Å c: 108.179Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.205 0.244
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The Escherichia coli FadR transcription factor: Too much of a good thing?
Cronan JE. (2021)
23 other articles

3 mentions without citation

The TetR family of regulators.
Cuthbertson et al. (2013)
2 more