Function and Biology Details
Reactions catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- DNA polymerase family X, beta-like
- Helix-hairpin-helix DNA-binding motif, class 1
- Nucleotidyltransferase superfamily
- DNA polymerase lambda lyase domain superfamily
- DNA-directed DNA polymerase X
- PHP domain
- Polymerase/histidinol phosphatase, N-terminal
- Polymerase/histidinol phosphatase-like
6 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
DNA polymerase beta and DNA (preferred)
PDBe Complex ID:
PDB-CPX-116070 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (3 distinct):
DNA polymerase beta
Molecule details ›
Chain: A
Length: 575 amino acids
Theoretical weight: 64.2 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 575 amino acids
Theoretical weight: 64.2 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli
UniProt:
- Canonical:
Q5SJ64 (Residues: 1-575; Coverage: 100%)
Sequence domains:
Structure domains:
