› 3ay5

X-ray diffraction
2.5Å resolution

Crystal structure of HHM (human homologue of murine maternal Id-like molecule)

Released:
DOI: 10.2210/pdb3ay5/pdb
PDB entry 3ay5 coloured by chain, front view.
PDB entry 3ay5 coloured by chain, side view.
PDB entry 3ay5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition.
Ishii R, Isogaya K, Seto A, Koinuma D, Watanabe Y, Arisaka F, Yaguchi S, Ikushima H, Dohmae N, Miyazono K, Miyazawa K, Ishitani R, Nureki O
EMBO J 31 2541-52 (2012)
PMID: 22453338

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131881 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-D1-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 40.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95273 (Residues: 1-360; Coverage: 100%)
Gene names: CCNDBP1, DIP1, GCIP, HHM
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P3221
Unit cell:
a: 105.031Å b: 105.031Å c: 124.266Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.222 0.261
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Common and Distinct Features of Adult Neurogenesis and Regeneration in the Telencephalon of Zebrafish and Mammals.
Diotel et al. (2020)
11 other articles

4 mentions without citation

Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition.
Ishii et al. (2012)
3 more