› 3b7d

X-ray diffraction
2.5Å resolution

Crystal structure of the GLUR2 ligand binding core (HS1S2J) in complex with CNQX at 2.5 A resolution

Released:
DOI: 10.2210/pdb3b7d/pdb
PDB entry 3b7d coloured by chain, front view.
PDB entry 3b7d coloured by chain, side view.
PDB entry 3b7d coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists.
Menuz K, Stroud RM, Nicoll RA, Hays FA
Science 318 815-7 (2007)
PMID: 17975069

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 261 amino acids
Theoretical weight: 29.08 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-794; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand CNI 8 x CNI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P1
Unit cell:
a: 66.582Å b: 97.631Å c: 100.97Å
α: 81.85° β: 89.08° γ: 77.89°
R-values:
R R work R free
0.256 0.255 0.283
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
24 more

6 mentions without citation

Structure of an agonist-bound ionotropic glutamate receptor.
Yelshanskaya et al. (2014)
5 more