› 3b9c

X-ray diffraction
1.9Å resolution

Crystal Structure of Human GRP CRD

Released:
DOI: 10.2210/pdb3b9c/pdb
PDB entry 3b9c coloured by chain, front view.
PDB entry 3b9c coloured by chain, side view.
PDB entry 3b9c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the C-terminal conserved domain of human GRP, a galectin-related protein, reveals a function mode different from those of galectins.
Zhou D, Ge H, Sun J, Gao Y, Teng M, Niu L
Proteins 71 1582-8 (2008)
PMID: 18320588

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174904 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-related protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 144 amino acids
Theoretical weight: 16.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q3ZCW2 (Residues: 38-172; Coverage: 79%)
Gene names: GRP, HSPC159, LGALSL
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand SO4 7 x SO4
Ligand BME 6 x BME
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 3W1A
Spacegroup: C2
Unit cell:
a: 123.14Å b: 96.67Å c: 61.57Å
α: 90° β: 118.79° γ: 90°
R-values:
R R work R free
0.224 0.221 0.266
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Roles of galectins in infection.
Vasta GR. (2009)
3 more

2 mentions without citation

Achieving universal electrification of rural healthcare facilities in sub-Saharan Africa with decentralized renewable energy technologies.
Moner-Girona et al. (2021)
1 more