› 3be8

X-ray diffraction
2.2Å resolution

Crystal structure of the synaptic protein neuroligin 4

Released:
DOI: 10.2210/pdb3be8/pdb
PDB entry 3be8 coloured by chain, front view.
PDB entry 3be8 coloured by chain, side view.
PDB entry 3be8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion.
Fabrichny IP, Leone P, Sulzenbacher G, Comoletti D, Miller MT, Taylor P, Bourne Y, Marchot P
Neuron 56 979-91 (2007)
PMID: 18093521

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185344 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuroligin-4, X-linked Chains: A, B
Molecule details ›
Chains: A, B
Length: 588 amino acids
Theoretical weight: 66.23 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8N0W4 (Residues: 44-619; Coverage: 74%)
Gene names: KIAA1260, NLGN4, NLGN4X, UNQ365/PRO701
Sequence domains: Carboxylesterase family
Structure domains: alpha/beta hydrolase

Ligands and Environments

6 bound ligands:
Ligand NAG 4 x NAG
Ligand FLC 2 x FLC
Ligand PO4 2 x PO4
Ligand CL 6 x CL
Ligand NA 1 x NA
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21212
Unit cell:
a: 139.73Å b: 154.05Å c: 81.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.167 0.201
Expression system: Homo sapiens

Quick links

Citations

22 review citations

Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits.
Südhof TC. (2017)
21 more

8 mentions without citation

Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion.
Fabrichny et al. (2007)
7 more