› 3bev

X-ray diffraction
2.1Å resolution

11mer Structure of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding

Released:
DOI: 10.2210/pdb3bev/pdb
PDB entry 3bev coloured by chain, front view.
PDB entry 3bev coloured by chain, side view.
PDB entry 3bev coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding.
Koch M, Camp S, Collen T, Avila D, Salomonsen J, Wallny HJ, van Hateren A, Hunt L, Jacob JP, Johnston F, Marston DA, Shaw I, Dunbar PR, Cerundolo V, Jones EY, Kaufman J
Immunity 27 885-99 (2007)
PMID: 18083574

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135389 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 31.13 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q95601 (Residues: 22-291; Coverage: 81%)
Gene names: B-FIV, BF2, BFIV21
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.19 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P21611 (Residues: 22-119; Coverage: 100%)
Gene name: B2M
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Hemoglobin subunit alpha-A Chain: C
Molecule details ›
Chain: C
Length: 11 amino acids
Theoretical weight: 1.18 KDa
Source organism: Gallus gallus
Expression system: Not provided
UniProt:
  • Canonical: P01994 (Residues: 20-30; Coverage: 8%)
Gene name: HBAA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P212121
Unit cell:
a: 71.306Å b: 72.199Å c: 72.711Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.23 0.286
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

16 review citations

The impact of host genetic variation on infection with HIV-1.
McLaren et al. (2015)
15 more

16 mentions without citation

New vistas unfold: Chicken MHC molecules reveal unexpected ways to present peptides to the immune system.
Halabi et al. (2022)
15 more