› 3bib

X-ray diffraction
2.5Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180403 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell immunoglobulin and mucin domain-containing protein 4 Chain: X
Molecule details ›
Chain: X
Length: 116 amino acids
Theoretical weight: 13.06 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q6U7R4 (Residues: 24-134; Coverage: 35%)
Gene names: Tim4, Timd4
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand NA 1 x NA
Ligand PSF 1 x PSF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P6322
Unit cell:
a: 66.26Å b: 66.26Å c: 139.39Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.221 0.219 0.248
Expression system: Escherichia coli BL21

Quick links

Citations

40 review citations

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.
Anderson et al. (2016)
39 more

13 mentions without citation

TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.
Freeman et al. (2010)
12 more