› 3bpz

X-ray diffraction
1.65Å resolution

HCN2-I 443-460 E502K in the presence of cAMP

Released:
DOI: 10.2210/pdb3bpz/pdb
Model geometry
Fit model/data
PDB entry 3bpz coloured by chain, front view.
PDB entry 3bpz coloured by chain, side view.
PDB entry 3bpz coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
C-terminal movement during gating in cyclic nucleotide-modulated channels.
Craven KB, Olivier NB, Zagotta WN
J Biol Chem 283 14728-38 (2008)
PMID: 18367452

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131576 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 202 amino acids
Theoretical weight: 23.63 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O88703 (Residues: 443-640; Coverage: 23%)
Gene names: Bcng2, Hac1, Hcn2
Sequence domains: Cyclic nucleotide-binding domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CMP 4 x CMP
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS BEAMLINE X26C
Spacegroup: C2221
Unit cell:
a: 123.899Å b: 134.264Å c: 134.359Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.19 0.216
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

The Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: from Biophysics to Pharmacology of a Unique Family of Ion Channels.
Sartiani et al. (2017)
6 more

4 mentions without citation

C-terminal movement during gating in cyclic nucleotide-modulated channels.
Craven et al. (2008)
3 more