› 3bs9

X-ray diffraction
1.95Å resolution

X-ray structure of human TIA-1 RRM2

Released:
DOI: 10.2210/pdb3bs9/pdb
PDB entry 3bs9 coloured by chain, front view.
PDB entry 3bs9 coloured by chain, side view.
PDB entry 3bs9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution.
Kumar AO, Swenson MC, Benning MM, Kielkopf CL
Biochem Biophys Res Commun 367 813-9 (2008)
PMID: 18201561

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-152017 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytotoxic granule associated RNA binding protein TIA1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 87 amino acids
Theoretical weight: 9.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31483 (Residues: 105-186; Coverage: 21%)
Gene name: TIA1
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

1 bound ligand:
Ligand IOD 7 x IOD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P61
Unit cell:
a: 56.5Å b: 56.5Å c: 76.7Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.216 0.245
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems.
Muto et al. (2012)
3 more

12 mentions without citation

Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1.
Wang et al. (2014)
11 more