› 3btn

X-ray diffraction
2.05Å resolution

Crystal structure of antizyme inhibitor, an ornithine decarboxylase homologous protein

Released:
DOI: 10.2210/pdb3btn/pdb
PDB entry 3btn coloured by chain, front view.
PDB entry 3btn coloured by chain, side view.
PDB entry 3btn coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function.
Albeck S, Dym O, Unger T, Snapir Z, Bercovich Z, Kahana C
Protein Sci 17 793-802 (2008)
PMID: 18369191

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-128691 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Antizyme inhibitor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 448 amino acids
Theoretical weight: 49.59 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O35484 (Residues: 1-448; Coverage: 100%)
Gene names: Azin1, Oazi, Oazin
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21212
Unit cell:
a: 92.769Å b: 98.389Å c: 117.331Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.241
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

13 review citations

Mammalian polyamine metabolism and function.
Pegg AE. (2009)
12 more

7 mentions without citation

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma.
Chen et al. (2013)
6 more