› 3bwr

X-ray diffraction
2.25Å resolution

SV40 VP1 pentamer in complex with GM1 oligosaccharide

Released:
DOI: 10.2210/pdb3bwr/pdb
PDB entry 3bwr coloured by chain, front view.
PDB entry 3bwr coloured by chain, side view.
PDB entry 3bwr coloured by chain, top view.
Source organism: Macaca mulatta polyomavirus 1
Primary publication:
Structural basis of GM1 ganglioside recognition by simian virus 40.
Neu U, Woellner K, Gauglitz G, Stehle T
Proc Natl Acad Sci U S A 105 5219-24 (2008)
PMID: 18353982

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136555 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Major capsid protein VP1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 272 amino acids
Theoretical weight: 29.73 KDa
Source organism: Macaca mulatta polyomavirus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P03087 (Residues: 31-298; Coverage: 74%)
Sequence domains: Polyomavirus coat protein
Structure domains: Capsid protein VP1,Polyomavirus

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, GAL, NGA, SIA
Carbohydrate polymer
1 bound ligand:
Ligand EDO 6 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 152.764Å b: 93.087Å c: 118.882Å
α: 90° β: 105.6° γ: 90°
R-values:
R R work R free
0.192 0.187 0.233
Expression system: Escherichia coli

Quick links

Citations

46 review citations

Mechanisms of endocytosis.
Doherty et al. (2009)
45 more

16 mentions without citation

Viruses and sialic acids: rules of engagement.
Neu et al. (2011)
15 more