› 3c27

X-ray diffraction
2.18Å resolution

Cyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors

Released:
DOI: 10.2210/pdb3c27/pdb
PDB entry 3c27 coloured by chain, front view.
PDB entry 3c27 coloured by chain, side view.
PDB entry 3c27 coloured by chain, top view.
Source organisms:
Entry authors: Spurlino JC, McMillan M, Lewandowski F, Milligan C

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133087 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain Chain: A
Molecule details ›
Chain: A
Length: 26 amino acids
Theoretical weight: 3.08 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 334-359; Coverage: 4%)
Gene name: F2
Sequence domains: Thrombin light chain
Thrombin heavy chain Chain: B
Molecule details ›
Chain: B
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Hirudin-2 Chain: H
Molecule details ›
Chain: H
Length: 11 amino acids
Theoretical weight: 1.41 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
  • Canonical: P28504 (Residues: 55-65; Coverage: 17%)

Ligands and Environments

1 bound ligand:
Ligand DKK 1 x DKK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE
Spacegroup: C2
Unit cell:
a: 70.854Å b: 72.026Å c: 72.987Å
α: 90° β: 100.5° γ: 90°
R-values:
R R work R free
0.176 0.174 0.215
Expression system: Not provided

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