› 3c5c

X-ray diffraction
1.85Å resolution

Crystal structure of human Ras-like, family 12 protein in complex with GDP

Released:
DOI: 10.2210/pdb3c5c/pdb
PDB entry 3c5c coloured by chain, front view.
PDB entry 3c5c coloured by chain, side view.
PDB entry 3c5c coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shen L, Tong Y, Tempel W, Loppnau P, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192717 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-like protein family member 12 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 187 amino acids
Theoretical weight: 21.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NYN1 (Residues: 18-186; Coverage: 64%)
Gene names: RASL12, RIS
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:
Ligand MG 7 x MG
Ligand GDP 4 x GDP
Ligand UNX 3 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P1
Unit cell:
a: 34.04Å b: 66.436Å c: 71.943Å
α: 101.46° β: 90.03° γ: 89.89°
R-values:
R R work R free
0.203 0.202 0.238
Expression system: Escherichia coli

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