› 3c64

X-ray diffraction
2.4Å resolution

The MC179 portion of the Cysteine-rich Interdomain Region (CIDR) of a Plasmodium falciparum Erythrocyte Membrane Protein-1 (PfEMP1)

Released:
DOI: 10.2210/pdb3c64/pdb
PDB entry 3c64 coloured by chain, front view.
PDB entry 3c64 coloured by chain, side view.
PDB entry 3c64 coloured by chain, top view.
Source organism: Plasmodium falciparum
Primary publication:
The cysteine-rich interdomain region from the highly variable plasmodium falciparum erythrocyte membrane protein-1 exhibits a conserved structure.
Klein MM, Gittis AG, Su HP, Makobongo MO, Moore JM, Singh S, Miller LH, Garboczi DN
PLoS Pathog. 4 e1000147 (2008)
PMID: 18773118

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173226 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PfEMP1 variant 1 of strain MC Chain: A
Molecule details ›
Chain: A
Length: 179 amino acids
Theoretical weight: 20.93 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q25733 (Residues: 576-754; Coverage: 6%)
Gene name: MCvar-1 PfEMP1
Sequence domains: PFEMP1 DBL domain
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1

Ligands and Environments

2 bound ligands:
Ligand CL 1 x CL
Ligand PG4 1 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P6522
Unit cell:
a: 93.31Å b: 93.31Å c: 85.71Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.246 0.246 0.289
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Malaria parasite proteins that remodel the host erythrocyte.
Maier et al. (2009)
12 more

5 mentions without citation

Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.
Clausen et al. (2012)
4 more