› 3c7r

X-ray diffraction
1.7Å resolution

Crystal Structure of HIV-1 subtype F DIS extended duplex RNA bound to neomycin

Released:
DOI: 10.2210/pdb3c7r/pdb
PDB entry 3c7r coloured by chain, front view.
PDB entry 3c7r coloured by chain, side view.
PDB entry 3c7r coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site.
Freisz S, Lang K, Micura R, Dumas P, Ennifar E
Angew Chem Int Ed Engl 47 4110-3 (2008)
PMID: 18435520

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113119 (preferred)
Entry contents:
1 distinct DNA/RNA hybrid molecule
Macromolecule:
HIV-1 subtype F genomic RNA Chains: A, B
Molecule details ›
Chains: A, B
Length: 23 nucleotides
Theoretical weight: 7.46 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand NMY 2 x NMY
Ligand K 2 x K
1 modified residue:
Ligand UMS 2 x UMS

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2
Unit cell:
a: 100.13Å b: 30.33Å c: 58.33Å
α: 90° β: 120.79° γ: 90°
R-values:
R R work R free
0.251 0.251 0.261
Expression system: Not provided

Quick links

Citations

6 review citations

Chemical RNA modifications for studies of RNA structure and dynamics.
Wachowius et al. (2010)
5 more

4 mentions without citation

Trendspotting in the Protein Data Bank.
Berman et al. (2013)
3 more