› 3c8m

X-ray diffraction
1.9Å resolution

Crystal structure of homoserine dehydrogenase from Thermoplasma volcanium

Released:
DOI: 10.2210/pdb3c8m/pdb
PDB entry 3c8m coloured by chain, front view.
PDB entry 3c8m coloured by chain, side view.
PDB entry 3c8m coloured by chain, top view.
Source organism: Thermoplasma volcanium GSS1
Entry authors: Osipiuk J, Hendricks R, Abdullah J, Joachimiak A, Midwest Center for Structural Genomics (MCSG)

Function and Biology Details

Reaction catalysed: 
L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188876 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
homoserine dehydrogenase Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 37.13 KDa
Source organism: Thermoplasma volcanium GSS1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q97BR6 (Residues: 1-328; Coverage: 100%)
Gene name: TVG0375766
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3221
Unit cell:
a: 108.404Å b: 108.404Å c: 60.458Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.157 0.156 0.177
Expression system: Escherichia coli BL21(DE3)

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