› 3c9j

X-ray diffraction
3.5Å resolution

The Crystal structure of Transmembrane domain of M2 protein and Amantadine complex

Released:
DOI: 10.2210/pdb3c9j/pdb
PDB entry 3c9j coloured by chain, front view.
PDB entry 3c9j coloured by chain, side view.
PDB entry 3c9j coloured by chain, top view.
Source organism: Influenza A virus (A/Hong Kong/156/97(H5N1))
Primary publication:
Structural basis for the function and inhibition of an influenza virus proton channel.
Stouffer AL, Acharya R, Salom D, Levine AS, Di Costanzo L, Soto CS, Tereshko V, Nanda V, Stayrook S, DeGrado WF
Nature 451 596-9 (2008)
PMID: 18235504

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130718 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 25 amino acids
Theoretical weight: 2.74 KDa
Source organism: Influenza A virus (A/Hong Kong/156/97(H5N1))
Expression system: Not provided
UniProt:
  • Canonical: O70632 (Residues: 22-46; Coverage: 26%)
Gene name: M

Ligands and Environments

1 bound ligand:
Ligand 308 1 x 308
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21212
Unit cell:
a: 60.397Å b: 57.833Å c: 38.105Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.293 0.291 0.317
Expression system: Not provided

Quick links

Citations

85 review citations

Viroporins: structure and biological functions.
Nieva et al. (2012)
84 more

43 mentions without citation

Influences of membrane mimetic environments on membrane protein structures.
Zhou et al. (2013)
42 more