› 3cbq

X-ray diffraction
1.82Å resolution

Crystal structure of the human REM2 GTPase with bound GDP

Released:
DOI: 10.2210/pdb3cbq/pdb
PDB entry 3cbq coloured by chain, front view.
PDB entry 3cbq coloured by chain, side view.
PDB entry 3cbq coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Nedyalkova L, Shen Y, Tong Y, Tempel W, MacKenzie F, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184942 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTP-binding protein REM 2 Chain: A
Molecule details ›
Chain: A
Length: 195 amino acids
Theoretical weight: 21.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IYK8 (Residues: 110-286; Coverage: 52%)
Gene name: REM2
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

4 bound ligands:
Ligand MG 1 x MG
Ligand GDP 1 x GDP
Ligand EDO 2 x EDO
Ligand UNX 1 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: C2221
Unit cell:
a: 64.143Å b: 64.33Å c: 73.204Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.249
Expression system: Escherichia coli

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