› 3cco

X-ray diffraction
2.2Å resolution

Structural adaptation and conservation in quadruplex-drug recognition

Released:
DOI: 10.2210/pdb3cco/pdb
PDB entry 3cco coloured by chain, front view.
PDB entry 3cco coloured by chain, side view.
PDB entry 3cco coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes.
Parkinson GN, Cuenca F, Neidle S
J Mol Biol 381 1145-56 (2008)
PMID: 18619463

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-116132 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*DTP*DAP*DGP*DGP*DGP*DTP*DTP*DAP*DGP*DGP*DGP*DT)-3') Chain: A
Molecule details ›
Chain: A
Length: 12 nucleotides
Theoretical weight: 3.77 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand NA 1 x NA
Ligand K 3 x K
Ligand NII 3 x NII
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P6422
Unit cell:
a: 61.35Å b: 61.35Å c: 43.63Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.257 0.254 0.303
Expression system: Not provided

Quick links

Citations

10 review citations

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Balasubramanian et al. (2011)
9 more

8 mentions without citation

The many twists and turns of DNA: template, telomere, tool, and target.
Egli et al. (2010)
7 more