› 3cdm

X-ray diffraction
2.1Å resolution

Structural adaptation and conservation in quadruplex-drug recognition

Released:
DOI: 10.2210/pdb3cdm/pdb
PDB entry 3cdm coloured by chain, front view.
PDB entry 3cdm coloured by chain, side view.
PDB entry 3cdm coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes.
Parkinson GN, Cuenca F, Neidle S
J Mol Biol 381 1145-56 (2008)
PMID: 18619463

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-116133 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*DT*DAP*DGP*DGP*DGP*DTP*DTP*DAP*DGP*DGP*DGP*DTP*DTP*DAP*DGP*DGP*DGP*DTP*DTP*DAP*DGP*DGP*DG)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 23 nucleotides
Theoretical weight: 7.29 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand NII 6 x NII
Ligand K 4 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 39.575Å b: 43.084Å c: 56.937Å
α: 90° β: 103.58° γ: 90°
R-values:
R R work R free
0.234 0.234 0.295
Expression system: Not provided

Quick links

Citations

10 review citations

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Balasubramanian et al. (2011)
9 more

16 mentions without citation

Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches.
Carabet et al. (2018)
15 more