› 3cig

X-ray diffraction
2.66Å resolution

Crystal structure of mouse TLR3 ectodomain

Released:
DOI: 10.2210/pdb3cig/pdb
PDB entry 3cig coloured by chain, front view.
PDB entry 3cig coloured by chain, side view.
PDB entry 3cig coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of toll-like receptor 3 signaling with double-stranded RNA.
Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM, Davies DR
Science 320 379-81 (2008)
PMID: 18420935

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189352 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (6 distinct):
Toll-like receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 697 amino acids
Theoretical weight: 79.63 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q99MB1 (Residues: 28-704; Coverage: 77%)
Gene name: Tlr3
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, NDG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, NDG, MAN, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, NDG, FUL, BMA
Carbohydrate polymer
2 bound ligands:
Ligand NAG 4 x NAG
Ligand FUC 1 x FUC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: I222
Unit cell:
a: 82.681Å b: 158.017Å c: 185.278Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.244 0.272
Expression system: Trichoplusia ni

Quick links

Citations

195 review citations

Pattern recognition receptors and inflammation.
Takeuchi et al. (2010)
194 more

19 mentions without citation

The structural biology of Toll-like receptors.
Botos et al. (2011)
18 more