› 3cou

X-ray diffraction
1.8Å resolution

Crystal structure of human Nudix motif 16 (NUDT16)

Released:
DOI: 10.2210/pdb3cou/pdb
PDB entry 3cou coloured by chain, front view.
PDB entry 3cou coloured by chain, side view.
PDB entry 3cou coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tresaugues L, Moche M, Arrowsmith CH, Berglund H, Busam RD, Collins R, Dahlgren LG, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Herman MD, Johansson A, Johansson I, Kallas A, Karlberg T, Kotenyova T, Lehtio L, Nilsson ME, Nyman T, Persson C, Sagemark J, Schueler H, Svensson L, Thorsell AG, Van Den Berg S, Welin M, Weigelt J, Wikstrom M, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] + H(2)O = N(7)-methylguanosine 5'-diphosphate + 5'-phospho-[mRNA]
IDP + H(2)O = IMP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-188435 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
U8 snoRNA-decapping enzyme Chain: A
Molecule details ›
Chain: A
Length: 217 amino acids
Theoretical weight: 23.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96DE0 (Residues: 1-195; Coverage: 100%)
Gene name: NUDT16
Sequence domains: NUDIX domain
Structure domains: Nucleoside Triphosphate Pyrophosphohydrolase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: F23
Unit cell:
a: 142.13Å b: 142.13Å c: 142.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.217
Expression system: Escherichia coli

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