› 3cqv

X-ray diffraction
1.9Å resolution

Crystal structure of Reverb beta in complex with heme

Released:
DOI: 10.2210/pdb3cqv/pdb
PDB entry 3cqv coloured by chain, front view.
PDB entry 3cqv coloured by chain, side view.
PDB entry 3cqv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta.
Pardee KI, Xu X, Reinking J, Schuetz A, Dong A, Liu S, Zhang R, Tiefenbach J, Lajoie G, Plotnikov AN, Botchkarev A, Krause HM, Edwards A
PLoS Biol 7 e43 (2009)
PMID: 19243223

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172135 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor subfamily 1 group D member 2 Chain: A
Molecule details ›
Chain: A
Length: 199 amino acids
Theoretical weight: 22.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14995 (Residues: 381-579; Coverage: 34%)
Gene name: NR1D2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand HEM 1 x HEM
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 73.428Å b: 48.623Å c: 68.954Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.235
Expression system: Escherichia coli

Quick links

Citations

28 review citations

Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics.
Huang et al. (2010)
27 more

13 mentions without citation

REV-ERB and ROR nuclear receptors as drug targets.
Kojetin et al. (2014)
12 more