› 3csp

X-ray diffraction
1.7Å resolution

Crystal structure of the DM2 mutant of myelin oligodendrocyte glycoprotein

Released:
DOI: 10.2210/pdb3csp/pdb
PDB entry 3csp coloured by chain, front view.
PDB entry 3csp coloured by chain, side view.
PDB entry 3csp coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents.
Breithaupt C, Schäfer B, Pellkofer H, Huber R, Linington C, Jacob U
J Immunol 181 1255-63 (2008)
PMID: 18606679

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179007 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myelin-oligodendrocyte glycoprotein Chain: A
Molecule details ›
Chain: A
Length: 139 amino acids
Theoretical weight: 15.9 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q63345 (Residues: 27-152; Coverage: 57%)
Gene name: Mog
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P3221
Unit cell:
a: 49.24Å b: 49.24Å c: 77.6Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.199 0.245
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Mechanisms of white matter damage in multiple sclerosis.
Lassmann H. (2014)
3 more

3 mentions without citation

3D Printing of Lotus Root-Like Biomimetic Materials for Cell Delivery and Tissue Regeneration.
Feng et al. (2017)
2 more