› 3cu7

X-ray diffraction
3.1Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-133860 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Complement C5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1676 amino acids
Theoretical weight: 188.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01031 (Residues: 1-1676; Coverage: 100%)
Gene names: C5, CPAMD4
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 2 x NAG
Ligand CD 9 x CD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P31
Unit cell:
a: 144.26Å b: 144.26Å c: 241Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.238 0.236 0.28

Quick links

Citations

23 review citations

Complement, a target for therapy in inflammatory and degenerative diseases.
Morgan et al. (2015)
22 more

24 mentions without citation

Novel mechanisms and functions of complement.
Hajishengallis et al. (2017)
23 more