We've built a new version of this page with an interactive 3D viewer. Try it out in beta and help us improve:

› 3cy1

X-ray diffraction
1.75Å resolution

Crystal structure of the cytochrome P450 CYP121 S279A mutant from M. tuberculosis

Released:
DOI: 10.2210/pdb3cy1/pdb
Model geometry
Fit model/data
PDB entry 3cy1 coloured by chain, front view.
PDB entry 3cy1 coloured by chain, side view.
PDB entry 3cy1 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Entry author: Leys D

Function and Biology Details

Reaction catalysed: 
cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced [2Fe-2S]-[ferredoxin] + O2 +2 H(+) = mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O.
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162004 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mycocyclosin synthase Chain: A
Molecule details ›
Chain: A
Length: 396 amino acids
Theoretical weight: 43.29 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WPP7 (Residues: 1-396; Coverage: 100%)
Gene names: MTCY339.34c, Rv2276, cyp121
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

2 bound ligands:
Ligand SO4 3 x SO4
Ligand HEM 1 x HEM
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P6522
Unit cell:
a: 77.67Å b: 77.67Å c: 263.503Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.185 0.211
Expression system: Escherichia coli

Quick links