› 3d29

X-ray diffraction
2.6Å resolution

Proteasome Inhibition by Fellutamide B

Released:
DOI: 10.2210/pdb3d29/pdb
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PDB entry 3d29 coloured by chain, front view.
PDB entry 3d29 coloured by chain, side view.
PDB entry 3d29 coloured by chain, top view.
Source organisms:
Primary publication:
Proteasome inhibition by fellutamide B induces nerve growth factor synthesis.
Hines J, Groll M, Fahnestock M, Crews CM
Chem Biol 15 501-12 (2008)
PMID: 18482702

Function and Biology Details

Reaction catalysed: 
Cleavage of peptide bonds with very broad specificity.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero 34-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-242305 (preferred)
Entry contents:
15 distinct polypeptide molecules
Macromolecules (15 distinct):
Proteasome subunit alpha type-2 Chains: A, O
Molecule details ›
Chains: A, O
Length: 250 amino acids
Theoretical weight: 27.19 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P23639 (Residues: 1-250; Coverage: 100%)
Gene names: PRE8, PRS4, YML092C
Sequence domains:
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit alpha type-3 Chains: B, P
Molecule details ›
Chains: B, P
Length: 244 amino acids
Theoretical weight: 27.05 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P23638 (Residues: 2-245; Coverage: 95%)
Gene names: PRE9, PRS5, YGR135W
Sequence domains:
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit alpha type-4 Chains: C, Q
Proteasome subunit alpha type-5 Chains: D, R
Proteasome subunit alpha type-6 Chains: E, S
Probable proteasome subunit alpha type-7 Chains: F, T
Proteasome subunit alpha type-1 Chains: G, U
Proteasome subunit beta type-2 Chains: H, V
Proteasome subunit beta type-3 Chains: I, W
Proteasome subunit beta type-4 Chains: J, X
Proteasome subunit beta type-5 Chains: K, Y
Proteasome subunit beta type-6 Chains: L, Z
Proteasome subunit beta type-7 Chains: 1, M
Proteasome subunit beta type-1 Chains: 2, N
Fellutamide B Chains: a, b, c, d, e, f

Ligands and Environments

1 bound ligand:
Ligand HXD 6 x HXD
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 134.272Å b: 301.58Å c: 143.454Å
α: 90° β: 112.7° γ: 90°
R-values:
R R work R free
0.241 0.24 0.266
Expression system: Not provided

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Citations

28 review citations

Proteasome inhibitors: an expanding army attacking a unique target.
Kisselev et al. (2012)
27 more

5 mentions without citation

Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system.
Buckley et al. (2014)
4 more

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