› 3d2q

X-ray diffraction
1.5Å resolution

Crystal structure of MBNL1 tandem zinc finger 3 and 4 domain

Released:
DOI: 10.2210/pdb3d2q/pdb
PDB entry 3d2q coloured by chain, front view.
PDB entry 3d2q coloured by chain, side view.
PDB entry 3d2q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1.
Teplova M, Patel DJ
Nat Struct Mol Biol 15 1343-51 (2008)
PMID: 19043415

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192541 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Muscleblind-like protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 70 amino acids
Theoretical weight: 8.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NR56 (Residues: 178-246; Coverage: 18%)
Gene names: EXP, KIAA0428, MBNL, MBNL1
Sequence domains:
Structure domains: Ribosomal Protein S8; Chain: A, domain 1

Ligands and Environments

1 bound ligand:
Ligand ZN 8 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 29.166Å b: 80.459Å c: 55.357Å
α: 90° β: 101.76° γ: 90°
R-values:
R R work R free
0.198 0.197 0.217
Expression system: Escherichia coli

Quick links

Citations

23 review citations

Role of RNA structure in regulating pre-mRNA splicing.
Warf et al. (2010)
22 more

7 mentions without citation

Terminal loop-mediated regulation of miRNA biogenesis: selectivity and mechanisms.
Castilla-Llorente et al. (2013)
6 more