Function and Biology Details
Reactions catalysed:
ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate
L-glutamine + H(2)O = L-glutamate + NH(3)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Phosphoribosylformylglycinamidine synthase subunit PurS
- Phosphoribosylformylglycinamidine synthase subunit PurQ
- Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily
- PurM-like, N-terminal domain superfamily
- PurM-like, C-terminal domain superfamily
- Phosphoribosylformylglycinamidine subunit PurL
- Class I glutamine amidotransferase-like
- PurM-like, N-terminal domain
4 more domains
Structure domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Phosphoribosylformylglycinamidine synthase (preferred)
PDBe Complex ID:
PDB-CPX-194750 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Phosphoribosylformylglycinamidine synthase subunit PurL
Molecule details ›
Chains: A, E, I
Length: 629 amino acids
Theoretical weight: 69.11 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 629 amino acids
Theoretical weight: 69.11 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
- Canonical:
Q9X0X3 (Residues: 1-603; Coverage: 100%)
Sequence domains:
- Formylglycinamide ribonucleotide amidotransferase linker domain
- AIR synthase related protein, N-terminal domain
- AIR synthase related protein, C-terminal domain
- Phosphoribosylformylglycinamidine synthase II C-terminus
Phosphoribosylformylglycinamidine synthase subunit PurS
Molecule details ›
Chains: B, C, F, G, J, K
Length: 82 amino acids
Theoretical weight: 9.66 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
Sequence domains: Phosphoribosylformylglycinamidine (FGAM) synthase
Structure domains: Phosphoribosylformylglycinamidine synthase subunit PurS
Length: 82 amino acids
Theoretical weight: 9.66 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
- Canonical: Q9X0X1 (Residues: 1-82; Coverage: 100%)
Sequence domains: Phosphoribosylformylglycinamidine (FGAM) synthase
Structure domains: Phosphoribosylformylglycinamidine synthase subunit PurS
Phosphoribosylformylglycinamidine synthase subunit PurQ
Molecule details ›
Chains: D, H, L
Length: 213 amino acids
Theoretical weight: 23.75 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains: Rossmann fold
Length: 213 amino acids
Theoretical weight: 23.75 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
- Canonical: Q9X0X2 (Residues: 1-213; Coverage: 100%)
Sequence domains:
Structure domains: Rossmann fold
