› 3d7c

X-ray diffraction
2.06Å resolution

Crystal structure of the bromodomain of human GCN5, the general control of amino-acid synthesis protein 5-like 2

Released:
DOI: 10.2210/pdb3d7c/pdb
PDB entry 3d7c coloured by chain, front view.
PDB entry 3d7c coloured by chain, side view.
PDB entry 3d7c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Histone recognition and large-scale structural analysis of the human bromodomain family.
Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S
Cell 149 214-31 (2012)
PMID: 22464331

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187767 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT2A Chains: A, B
Molecule details ›
Chains: A, B
Length: 112 amino acids
Theoretical weight: 13.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92830 (Residues: 729-837; Coverage: 13%)
Gene names: GCN5, GCN5L2, KAT2A
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 45.428Å b: 72.862Å c: 75.89Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.179 0.257
Expression system: Escherichia coli

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Citations

244 review citations

Modification of enhancer chromatin: what, how, and why?
Calo et al. (2013)
243 more

11 mentions without citation

Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives.
Andreoli et al. (2013)
10 more