› 3dfj

X-ray diffraction
1.45Å resolution

Crystal structure of human Prostasin

Released:
DOI: 10.2210/pdb3dfj/pdb
PDB entry 3dfj coloured by chain, front view.
PDB entry 3dfj coloured by chain, side view.
PDB entry 3dfj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human prostasin, a target for the regulation of hypertension.
Rickert KW, Kelley P, Byrne NJ, Diehl RE, Hall DL, Montalvo AM, Reid JC, Shipman JM, Thomas BW, Munshi SK, Darke PL, Su HP
J Biol Chem 283 34864-72 (2008)
PMID: 18922802

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172540 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostasin heavy chain Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 28.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16651 (Residues: 45-289; Coverage: 78%)
Gene name: PRSS8
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 52.988Å b: 56.241Å c: 82.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.19 0.213
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Membrane-anchored serine proteases in health and disease.
Antalis et al. (2011)
6 more

5 mentions without citation

Serine proteases.
Di Cera E. (2009)
4 more