› 3dg1

X-ray diffraction
1.66Å resolution

Segment SSTNVG derived from IAPP

Released:
DOI: 10.2210/pdb3dg1/pdb
PDB entry 3dg1 coloured by chain, front view.
PDB entry 3dg1 coloured by chain, side view.
PDB entry 3dg1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin).
Wiltzius JJ, Sievers SA, Sawaya MR, Cascio D, Popov D, Riekel C, Eisenberg D
Protein Sci 17 1467-74 (2008)
PMID: 18556473

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145623 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Islet amyloid polypeptide Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 564 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10997 (Residues: 61-66; Coverage: 9%)
Gene name: IAPP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 41.4Å b: 4.785Å c: 18.594Å
α: 90° β: 115.88° γ: 90°
R-values:
R R work R free
0.211 0.207 0.244
Expression system: Not provided

Quick links

Citations

44 review citations

Islet amyloid polypeptide, islet amyloid, and diabetes mellitus.
Westermark et al. (2011)
43 more

7 mentions without citation

Linking hIAPP misfolding and aggregation with type 2 diabetes mellitus: a structural perspective.
Hassan et al. (2022)
6 more