› 3dgz

X-ray diffraction
2.25Å resolution

Crystal Structure of Mouse Mitochondrial Thioredoxin Reductase, C-terminal 3-residue truncation

Released:
DOI: 10.2210/pdb3dgz/pdb
PDB entry 3dgz coloured by chain, front view.
PDB entry 3dgz coloured by chain, side view.
PDB entry 3dgz coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Eckenroth BE, Hondal RJ, Everse SJ

Function and Biology Details

Reaction catalysed: 
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191642 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin reductase 2, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 488 amino acids
Theoretical weight: 52.86 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9JLT4 (Residues: 34-521; Coverage: 93%)
Gene names: Trxr2, Txnrd2
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 1 x FAD
1 bound ligand:
Ligand NA7 1 x NA7
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: I4122
Unit cell:
a: 110.507Å b: 110.507Å c: 208.025Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.193 0.258
Expression system: Escherichia coli

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