› 3dh1

X-ray diffraction
2.8Å resolution

Crystal structure of human tRNA-specific adenosine-34 deaminase subunit ADAT2

Released:
DOI: 10.2210/pdb3dh1/pdb
PDB entry 3dh1 coloured by chain, front view.
PDB entry 3dh1 coloured by chain, side view.
PDB entry 3dh1 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Welin M, Tresaugues L, Andersson J, Arrowsmith CH, Berglund H, Collins R, Dahlgren LG, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson A, Johansson I, Karlberg T, Kotenyova T, Lehtio L, Moche M, Nilsson ME, Nyman T, Olesen K, Persson C, Sagemark J, Schueler H, Thorsell AG, van der Berg S, Wisniewska M, Wikstrom M, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Adenine(34) in tRNA + H(2)O = hypoxanthine(34) in tRNA + NH(3)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182300 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
tRNA-specific adenosine deaminase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 189 amino acids
Theoretical weight: 21.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7Z6V5 (Residues: 20-185; Coverage: 87%)
Gene names: ADAT2, DEADC1
Sequence domains: MafB19-like deaminase
Structure domains: Cytidine Deaminase, domain 2

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 47.53Å b: 103.12Å c: 77.59Å
α: 90° β: 97.6° γ: 90°
R-values:
R R work R free
0.205 0.202 0.256
Expression system: Escherichia coli

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