› 3dh4

X-ray diffraction
2.7Å resolution

Crystal Structure of Sodium/Sugar symporter with bound Galactose from vibrio parahaemolyticus

Released:
DOI: 10.2210/pdb3dh4/pdb
PDB entry 3dh4 coloured by chain, front view.
PDB entry 3dh4 coloured by chain, side view.
PDB entry 3dh4 coloured by chain, top view.
Source organism: Vibrio parahaemolyticus
Primary publication:
The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport.
Faham S, Watanabe A, Besserer GM, Cascio D, Specht A, Hirayama BA, Wright EM, Abramson J
Science 321 810-4 (2008)
PMID: 18599740

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161207 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium/glucose cotransporter Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 530 amino acids
Theoretical weight: 56.93 KDa
Source organism: Vibrio parahaemolyticus
Expression system: Escherichia coli
UniProt:
  • Canonical: P96169 (Residues: 47-543; Coverage: 92%)
Gene name: sglT
Sequence domains: Sodium:solute symporter family
Structure domains: Sodium/glucose cotransporter

Ligands and Environments

3 bound ligands:
Ligand GAL 4 x GAL
Ligand ER3 4 x ER3
Ligand NA 4 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P1
Unit cell:
a: 83.28Å b: 109.21Å c: 127.58Å
α: 109.7° β: 92.02° γ: 102.11°
R-values:
R R work R free
0.271 0.27 0.287
Expression system: Escherichia coli

Quick links

Citations

85 review citations

Biology of human sodium glucose transporters.
Wright et al. (2011)
84 more

70 mentions without citation

Unlocking the molecular secrets of sodium-coupled transporters.
Krishnamurthy et al. (2009)
69 more