› 3dmk

X-ray diffraction
4.19Å resolution

Crystal structure of Down Syndrome Cell Adhesion Molecule (DSCAM) isoform 1.30.30, N-terminal eight Ig domains

Released:
DOI: 10.2210/pdb3dmk/pdb
PDB entry 3dmk coloured by chain, front view.
PDB entry 3dmk coloured by chain, side view.
PDB entry 3dmk coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms.
Sawaya MR, Wojtowicz WM, Andre I, Qian B, Wu W, Baker D, Eisenberg D, Zipursky SL
Cell 134 1007-18 (2008)
PMID: 18805093

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192416 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Cell adhesion molecule Dscam1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 816 amino acids
Theoretical weight: 89.73 KDa
Source organism: Drosophila melanogaster
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q0E9H9 (Residues: 1-265, 266-810; Coverage: 39%)
Gene names: CG17800, Dscam, Dscam1, p270
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand GOL 4 x GOL
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: I222
Unit cell:
a: 118.46Å b: 177.61Å c: 434.05Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.282 0.28 0.327
Expression system: Trichoplusia ni

Quick links

Citations

22 review citations

Immune proteins in brain development and synaptic plasticity.
Boulanger LM. (2009)
21 more

15 mentions without citation

Homophilic interaction of the L1 family of cell adhesion molecules.
Wei et al. (2012)
14 more