› 3dpu

X-ray diffraction
2.9Å resolution

RocCOR domain tandem of Rab family protein (Roco)

Released:
DOI: 10.2210/pdb3dpu/pdb
PDB entry 3dpu coloured by chain, front view.
PDB entry 3dpu coloured by chain, side view.
PDB entry 3dpu coloured by chain, top view.
Source organism: Chlorobaculum tepidum
Primary publication:
Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase.
Gotthardt K, Weyand M, Kortholt A, Van Haastert PJ, Wittinghofer A
EMBO J 27 2239-49 (2008)
PMID: 18650931

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185110 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Roc domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 535 amino acids
Theoretical weight: 61.61 KDa
Source organism: Chlorobaculum tepidum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8KC98 (Residues: 412-946; Coverage: 49%)
Gene name: CT1526
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 83.2Å b: 106.1Å c: 139Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.23 0.27
Expression system: Escherichia coli

Quick links

Citations

34 review citations

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.
Exner et al. (2012)
33 more

15 mentions without citation

Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation.
Gilsbach et al. (2014)
14 more