› 3drn

X-ray diffraction
2.15Å resolution

The crystal structure of Bcp1 from Sulfolobus Sulfataricus

Released:
DOI: 10.2210/pdb3drn/pdb
PDB entry 3drn coloured by chain, front view.
PDB entry 3drn coloured by chain, side view.
PDB entry 3drn coloured by chain, top view.
Source organism: Saccharolobus solfataricus
Primary publication:
Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus.
D'Ambrosio K, Limauro D, Pedone E, Galdi I, Pedone C, Bartolucci S, De Simone G
Proteins 76 995-1006 (2009)
PMID: 19338062

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189019 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
thioredoxin-dependent peroxiredoxin Chains: A, B
Molecule details ›
Chains: A, B
Length: 161 amino acids
Theoretical weight: 18.53 KDa
Source organism: Saccharolobus solfataricus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q97WP9 (Residues: 1-153; Coverage: 100%)
Gene names: SSO2071, bcp-1
Sequence domains: AhpC/TSA family
Structure domains: Glutaredoxin

Ligands and Environments

2 bound ligands:
Ligand CIT 2 x CIT
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P21
Unit cell:
a: 42.841Å b: 91.829Å c: 52.542Å
α: 90° β: 95.74° γ: 90°
R-values:
R R work R free
0.189 0.189 0.238
Expression system: Escherichia coli

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Citations

4 review citations

Peroxiredoxin: a central player in immune modulation.
Robinson et al. (2010)
3 more

7 mentions without citation

Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.
Hall et al. (2011)
6 more