› 3du6

X-ray diffraction
2.71Å resolution

Structure of the catalytic subunit of telomerase, TERT

Released:
DOI: 10.2210/pdb3du6/pdb
PDB entry 3du6 coloured by chain, front view.
PDB entry 3du6 coloured by chain, side view.
PDB entry 3du6 coloured by chain, top view.
Source organism: Tribolium castaneum
Primary publication:
Structure of the Tribolium castaneum telomerase catalytic subunit TERT.
Gillis AJ, Schuller AP, Skordalakes E
Nature 455 633-7 (2008)
PMID: 18758444

Function and Biology Details

Reaction catalysed: 
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171089 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Telomerase reverse transcriptase Chains: A, B
Molecule details ›
Chains: A, B
Length: 596 amino acids
Theoretical weight: 70.59 KDa
Source organism: Tribolium castaneum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q0QHL8 (Residues: 1-596; Coverage: 100%)
Gene names: AUGUSTUS-3.0.2_10963, TERT, TcasGA2_TC010963
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P212121
Unit cell:
a: 85.042Å b: 122.657Å c: 212.406Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.238 0.278
Expression system: Escherichia coli

Quick links

Citations

52 review citations

Telomeres and telomerase: three decades of progress.
Shay et al. (2019)
51 more

25 mentions without citation

Telomerase and telomere-associated proteins: structural insights into mechanism and evolution.
Lewis et al. (2012)
24 more